Cognitive dysfunction after experimental febrile seizures

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Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis.

Experimental prolonged febrile seizures (FS) lead to structural and molecular changes that promote hippocampal hyperexcitability and reduce seizure threshold to further convulsants. However, whether these seizures provoke later-onset epilepsy, as has been suspected in humans, has remained unclear. Previously, intermittent EEGs with behavioural observations for motor seizures failed to demonstra...

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Febrile seizures.

BACKGROUND Febrile convulsions, or febrile seizures, are frequently encountered in paediatrics, and despite often being self limiting, these seizures strike fear in the hearts of patients' carers. OBJECTIVE This article reviews the assessment and management of febrile seizures in children. DISCUSSION The initial assessment of a child who convulses with fever should be directed at finding a ...

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Febrile seizures

Febrile seizure (FS) is the most common seizure disorder of childhood, and occurs in an age-related manner. FS are classified into simple and complex. FS has a multifactorial inheritance, suggesting that both genetic and environmental factors are causative. Various animal models have elucidated the pathophysiological mechanisms of FS. Risk factors for a first FS are a family history of the diso...

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ژورنال

عنوان ژورنال: Experimental Neurology

سال: 2009

ISSN: 0014-4886

DOI: 10.1016/j.expneurol.2008.10.003